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Symbol
Name
ID

Aicda
activation-induced cytidine deaminase
MGI:1342279

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Decreased circulating IgA level	Decreased circulating IgG level	Increased circulating IgM level	Complete or near-complete absence of specific antibody response to tetanus vaccine	Impaired Ig class switch recombination	Recurrent upper and lower respiratory tract infections	Lymphadenopathy	Recurrent infection of the gastrointestinal tract	Immunodeficiency	Recurrent bacterial infections	Recurrent respiratory infections
Disease(s) Associated with AICDA
immunodeficiency with hyper-IgM type 2

Mouse Phenotypes

immune system phenotype

abnormal class switch recombination

abnormal somatic hypermutation frequency

increased early germinal center B cell number

decreased late germinal center B cell number

increased germinal center B cell number

decreased follicular B cell number

increased leukocyte cell number

abnormal splenic cell ratio

decreased IgA level

decreased IgE level

decreased IgG1 level

decreased IgG2a level

decreased IgG2b level

decreased IgG3 level

decreased IgG level

increased IgM level

abnormal Peyer's patch germinal center morphology

abnormal lymph node cell ratio

abnormal humoral immune response

increased susceptibility to bacterial infection

increased susceptibility to bacterial infection induced morbidity/mortality

Availability

Mouse Genotype

Aicda^em1Jaych/Aicda^em1Jaych

Aicda^m1Btlr/Aicda^m1Btlr

Aicda^m2Btlr/Aicda^m2Btlr

Aicda^tm1.1Fwa/Aicda^tm1.1Fwa

*

Aicda^{tm1b(EUCOMM)Hmgu}/Aicda^{tm1b(EUCOMM)Hmgu}

Aicda^tm1Hon/Aicda^tm1Hon

Aicda^tm2.1Hon/Aicda^tm2.1Hon

*

Aicda^tm2Mnz/Aicda^tm2Mnz

*

Aicda^tm3.1Mnz/Aicda^tm3.1Mnz

Aicda^tm4.1Mnz/Aicda^tm4.1Mnz

Aicda^tm1Hon/Aicda⁺

*

Aicda^tm1Hon/Aicda^tm1.1Fwa

*

Aicda^tm1Hon/Aicda^tm2Mnz

*

Aicda^tm1Hon/Aicda^tm3Mnz

Aicda^tm1Hon/Aicda^tm4Mnz

Aicda^tm3Mnz/Aicda⁺

Aicda^tm4Mnz/Aicda⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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